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	lupus erythematosus

Disease ID	804
Disease	lupus erythematosus
Definition	What is lupus? Lupus is an autoimmune disease. This means that your immune system attacks healthy cells and tissues by mistake. This can damage many parts of the body, including the joints, skin, kidneys, heart, lungs, blood vessels, and brain. There are several kinds of lupus Systemic lupus erythematosus (SLE) is the most common type. It can be mild or severe, and can affect many parts of the body. Discoid lupus causes a red rash that doesn't go away Subacute cutaneous lupus causes sores after being out in the sun Drug-induced lupus is caused by certain medicines. It usually goes away when you stop taking the medicine. Neonatal lupus, which is rare, affects newborns. It is probably caused by certain antibodies from the mother. Who gets lupus? Anyone can get lupus, but women are most at risk. Lupus is two to three times more common in African American women than in Caucasian women. It's also more common in Hispanic, Asian, and Native American women. African American and Hispanic women are more likely to have severe forms of lupus. What causes lupus? The cause of lupus is not known. What are the symptoms of lupus? Lupus can have many symptoms, and they differ from person to person. Some of the more common ones are Pain or swelling in joints Muscle pain Fever with no known cause Red rashes, most often on the face (also called the "butterfly rash") Chest pain when taking a deep breath Hair loss Pale or purple fingers or toes Sensitivity to the sun Swelling in legs or around eyes Mouth ulcers Swollen glands Feeling very tired Symptoms may come and go. When you are having symptoms, it is called a flare. Flares can range from mild to severe. New symptoms may appear at any time. How do I know if I have lupus? There is no single test to diagnose lupus, and it's often mistaken for other diseases. So it may take months or years for a doctor to diagnose it. Your doctor may use many tools to make a diagnosis: Medical history Complete exam Blood tests Skin biopsy (looking at skin samples under a microscope) Kidney biopsy (looking at tissue from your kidney under a microscope) What are the treatments for lupus? There is no cure for lupus, but medicines and lifestyle changes can help control it. People with lupus often need to see different doctors. You will have a primary care doctor and a rheumatologist (a doctor who specializes in the diseases of joints and muscles). Which other specialists you see depends on how lupus affects your body. For example, if lupus damages your heart or blood vessels, you would see a cardiologist. Your primary care doctor should coordinate care between your different health care providers and treat other problems as they come up. Your doctor will develop a treatment plan to fit your needs. You and your doctor should review the plan often to be sure it is working. You should report new symptoms to your doctor right away so that your treatment plan can be changed if needed. The goals of the treatment plan are to Prevent flares Treat flares when they occur Reduce organ damage and other problems Treatments may include drugs to Reduce swelling and pain Prevent or reduce flares Help the immune system Reduce or prevent damage to joints Balance the hormones Besides taking medicines for lupus, you may need to take medicines for problems that are related to lupus such as high cholesterol, high blood pressure, or infection. Alternative treatments are those that are not part of standard treatment. At this time, no research shows that alternative medicine can treat lupus. Some alternative or complementary approaches may help you cope or reduce some of the stress associated with living with a chronic illness. You should talk to your doctor before trying any alternative treatments. How can I cope with lupus? It is important to take an active role in your treatment. It helps to learn more about lupus - being able to spot the warning signs of a flare can help you prevent the flare or make the symptoms less severe. It is also important to find ways to cope with the stress of having lupus. Exercising and finding ways to relax may make it easier for you to cope. A good support system can also help. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases
Synonym	le - lupus erythematosus lupus erythematosus (disorder) lupus erythematosus nos lupus erythematosus nos (disorder)
DOID	DOID:8857
UMLS	C0409974
SNOMED-CT	SNOMEDCT_US_2016_09_01:200936003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:367) C0027697 \| nephritis \| 32 C0004153 \| atherosclerosis \| 29 C0024143 \| lupus nephritis \| 27 C0085278 \| antiphospholipid syndrome \| 21 C0042384 \| vasculitis \| 19 C0040034 \| thrombocytopenia \| 16 C0042373 \| vascular disease \| 13 C0003864 \| arthritis \| 13 C0020538 \| hypertension \| 11 C0034150 \| purpura \| 10 C0040053 \| thrombosis \| 9 C0007222 \| cardiovascular disease \| 9 C0022658 \| renal disease \| 9 C0042769 \| virus infection \| 9 C0033975 \| psychosis \| 9 C0034155 \| thrombotic thrombocytopenic purpura \| 8 C0017658 \| glomerulonephritis \| 8 C0011570 \| depression \| 8 C0002871 \| anemia \| 7 C0021053 \| immune disease \| 6 C0027051 \| myocardial infarction \| 6 C0026896 \| myasthenia gravis \| 6 C0948265 \| metabolic syndrome \| 6 C0020542 \| pulmonary hypertension \| 6 C0027051 \| myocardial infarct \| 6 C0041296 \| tuberculosis \| 6 C0003873 \| rheumatoid arthritis \| 6 C0022658 \| nephropathy \| 6 C0162855 \| mucinosis \| 5 C0006663 \| calcinosis \| 5 C0027121 \| myositis \| 5 C0011603 \| dermatitis \| 5 C0021847 \| intestinal pseudo-obstruction \| 4 C0007137 \| squamous cell carcinoma \| 4 C0030305 \| pancreatitis \| 4 C0014544 \| epilepsy \| 4 C0442874 \| neuropathy \| 4 C0002871 \| anaemia \| 4 C0019360 \| zoster \| 4 C0026946 \| fungal infection \| 4 C0021831 \| enteropathy \| 4 C0032285 \| pneumonia \| 4 C0002874 \| aplastic anemia \| 4 C0024141 \| systemic lupus erythematosus \| 4 C0004030 \| aspergillosis \| 4 C0003467 \| anxiety \| 4 C0024299 \| lymphoma \| 4 C0010346 \| crohn's disease \| 4 C0019360 \| herpes zoster \| 4 C0035309 \| retinopathy \| 4 C0019163 \| hepatitis b \| 4 C0031117 \| peripheral neuropathy \| 4 C0024291 \| hemophagocytic syndrome \| 4 C0027947 \| neutropenia \| 4 C0014742 \| erythema multiforme \| 4 C0021400 \| influenza \| 4 C0155626 \| acute myocardial infarction \| 4 C0003486 \| aortic aneurysm \| 3 C0019158 \| hepatitis \| 3 C0001339 \| acute pancreatitis \| 3 C0024115 \| lung disease \| 3 C1527336 \| sjogren's syndrome \| 3 C0033680 \| protein-losing enteropathy \| 3 C0024312 \| lymphopenia \| 3 C0035078 \| renal failure \| 3 C0026975 \| myelitis \| 3 C0001815 \| myelofibrosis \| 3 C0009782 \| connective tissue disease \| 3 C0042870 \| vitamin d deficiency \| 3 C0015230 \| rash \| 3 C0042870 \| vitamin d defic \| 3 C0026654 \| moyamoya syndrome \| 3 C0007642 \| cellulitis \| 3 C0040128 \| thyroid disease \| 3 C0034735 \| raynaud's phenomenon \| 3 C0011847 \| diabetes \| 3 C0022735 \| klinefelter's syndrome \| 3 C0026654 \| moyamoya \| 3 C0270612 \| leukoencephalopathy \| 3 C0011849 \| diabetes mellitus \| 3 C0027873 \| neuromyelitis optica \| 3 C0010068 \| coronary artery disease \| 3 C0039263 \| takayasu's arteritis \| 2 C0004096 \| asthma \| 2 C0026764 \| multiple myeloma \| 2 C0032285 \| pneumonitis \| 2 C0030326 \| panniculitis \| 2 C0031117 \| peripheral neuropathies \| 2 C0600260 \| obstructive pulmonary disease \| 2 C0149931 \| migraine \| 2 C0002880 \| autoimmune hemolytic anemia \| 2 C0022116 \| ischemia \| 2 C0022661 \| end-stage renal disease \| 2 C1704275 \| pyomyositis \| 2 C0035302 \| retinal artery occlusion \| 2 C0000786 \| miscarriage \| 2 C0006666 \| calciphylaxis \| 2 C0035333 \| retinitis \| 2 C0022658 \| kidney disease \| 2 C0206062 \| interstitial lung disease \| 2 C1619734 \| pulmonary arterial hypertension \| 2 C0004623 \| bacterial infection \| 2 C0020455 \| hypergammaglobulinemia \| 2 C0042373 \| vascular diseases \| 2 C0032326 \| pneumothorax \| 2 C0022661 \| chronic kidney disease \| 2 C0241910 \| autoimmune hepatitis \| 2 C0852949 \| arterial disease \| 2 C0151740 \| intracranial hypertension \| 2 C0026272 \| mixed connective tissue disease \| 2 C0039614 \| tetanus \| 2 C0038325 \| stevens-johnson syndrome \| 2 C0021655 \| insulin resistance syndrome \| 2 C0009319 \| colitis \| 2 C0034902 \| pure red cell aplasia \| 2 C0085278 \| anti-phospholipid syndrome \| 2 C0011644 \| scleroderma \| 2 C0025289 \| meningitis \| 2 C0024115 \| pulmonary disease \| 2 C0040100 \| thymoma \| 2 C1704436 \| peripheral arterial disease \| 2 C0026946 \| fungal infections \| 2 C0026764 \| myeloma \| 2 C0085278 \| antiphospholipid antibody syndrome \| 2 C0024314 \| lymphoproliferative disorder \| 2 C0007177 \| cardiac tamponade \| 2 C0032231 \| pleuritis \| 2 C0014306 \| enophthalmos \| 2 C0037198 \| sinus thrombosis \| 2 C0004623 \| bacterial infections \| 2 C0011615 \| atopic dermatitis \| 2 C0003504 \| aortic regurgitation \| 2 C0024117 \| chronic obstructive pulmonary disease \| 2 C0272242 \| complement deficiency \| 2 C0032285 \| pneumoniae \| 2 C0023895 \| liver disease \| 2 C0033860 \| psoriasis \| 2 C0002878 \| hemolytic anemia \| 2 C0017661 \| iga nephropathy \| 2 C0021359 \| infertile \| 2 C0272126 \| evans syndrome \| 1 C0022660 \| acute renal failure \| 1 C0014070 \| encephalomyelitis \| 1 C0079731 \| b cell lymphoma \| 1 C0162566 \| porphyria cutanea tarda \| 1 C0032587 \| polyradiculoneuropathy \| 1 C0017668 \| focal segmental glomerulosclerosis \| 1 C0152026 \| retinal vasculitis \| 1 C0001430 \| adenoma \| 1 C0035328 \| retinal vein occlusion \| 1 C0031212 \| personality disorders \| 1 C0041321 \| miliary tuberculosis \| 1 C0178664 \| glomerulosclerosis \| 1 C0010414 \| cryptococcus neoformans \| 1 C0020676 \| hypothyroid \| 1 C0014175 \| endometriosis \| 1 C0021345 \| infectious mononucleosis \| 1 C0020502 \| hyperparathyroidism \| 1 C0030499 \| parasitic disease \| 1 C0007115 \| thyroid ca \| 1 C0026848 \| myopathy \| 1 C0878544 \| cardiomyopathy \| 1 C0079293 \| epidermolysis bullosa acquisita \| 1 C1527383 \| morphea \| 1 C1262481 \| eosinophilic gastroenteritis \| 1 C0001175 \| acquired immune deficiency \| 1 C0035579 \| hypovitaminosis d \| 1 C0549473 \| thyroid carcinoma \| 1 C0017605 \| angle closure glaucoma \| 1 C0035435 \| rheumatic disease \| 1 C0004943 \| behcet's disease \| 1 C0019196 \| hepatitis c \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0314719 \| dry eye \| 1 C0393819 \| chronic inflammatory demyelinating polyradiculoneuropathy \| 1 C0020295 \| hydronephrosis \| 1 C0038362 \| stomatitis \| 1 C0010051 \| coronary aneurysm \| 1 C0040147 \| thyroiditis \| 1 C0007222 \| cardiovascular disorders \| 1 C0031069 \| familial mediterranean fever \| 1 C0085293 \| hepatitis e \| 1 C1263846 \| attention deficit hyperactivity disorder \| 1 C0012569 \| diplopia \| 1 C0035302 \| retinal artery occlusions \| 1 C0030807 \| pemphigus \| 1 C0027726 \| nephrotic syndrome \| 1 C0001815 \| bone marrow fibrosis \| 1 C0281658 \| primary intraocular lymphoma \| 1 C0023343 \| hansen's disease \| 1 C1290398 \| cerebral artery aneurysm \| 1 C0035258 \| restless legs syndrome (rls) \| 1 C0011608 \| dermatitis herpetiformis \| 1 C0018801 \| heart failure \| 1 C0022735 \| klinefelter syndrome \| 1 C0023860 \| listeria monocytogenes infection \| 1 C0003850 \| arteriosclerosis \| 1 C0085436 \| cryptococcal meningitis \| 1 C0007222 \| cardiovascular diseases \| 1 C0027721 \| minimal change nephropathy \| 1 C0014059 \| acute disseminated encephalomyelitis \| 1 C0033680 \| protein losing enteropathy \| 1 C0007193 \| dilated cardiomyopathies \| 1 C0024623 \| gastric cancer \| 1 C0012546 \| diphtheria \| 1 C0030354 \| papilloma \| 1 C0042373 \| vascular disorders \| 1 C0020503 \| secondary hyperparathyroidism \| 1 C0002878 \| haemolytic anaemia \| 1 C0206157 \| nemaline myopathy \| 1 C0041309 \| tuberculosis cutis \| 1 C0019069 \| hemophilia \| 1 C0013592 \| ectropion \| 1 C0034069 \| pulmonary fibrosis \| 1 C0036416 \| scleritis \| 1 C0019202 \| wilson's disease \| 1 C0021831 \| bowel disease \| 1 C0155357 \| posterior scleritis \| 1 C0022656 \| renal cortical necrosis \| 1 C0151311 \| cranial nerve palsy \| 1 C0034065 \| pulmonary embolism \| 1 C1510471 \| hypovitaminosis \| 1 C0020626 \| hypoparathyroidism \| 1 C0030499 \| parasitic diseases \| 1 C0018378 \| guillain-barre syndrome \| 1 C0023524 \| progressive multifocal leukoencephalopathy \| 1 C0019048 \| hemoglobinuria \| 1 C0023646 \| lichen planus \| 1 C0272286 \| immune thrombocytopenia \| 1 C0017601 \| glaucoma \| 1 C0007847 \| cervical cancer \| 1 C0023890 \| liver cirrhosis \| 1 C0751878 \| cns vasculitis \| 1 C0025309 \| meningoencephalitis \| 1 C0920350 \| autoimmune thyroiditis \| 1 C0679466 \| cognitive deficits \| 1 C0010068 \| coronary heart disease \| 1 C0041296 \| mycobacterium tuberculosis infection \| 1 C0032305 \| pneumocystis \| 1 C0043092 \| wegener granulomatosis \| 1 C0023895 \| liver diseases \| 1 C0018784 \| sensorineural hearing loss \| 1 C0302592 \| cervical ca \| 1 C0040128 \| thyroid diseases \| 1 C0038220 \| status epilepticus \| 1 C0031046 \| pericarditis \| 1 C0003874 \| septic arthritis \| 1 C0006625 \| cachexia \| 1 C0087086 \| thrombi \| 1 C0032305 \| pneumocystis jiroveci pneumonia \| 1 C0035078 \| kidney failure \| 1 C0553723 \| cutaneous squamous cell carcinoma \| 1 C0007688 \| central retinal artery occlusion \| 1 C0018799 \| heart disease \| 1 C0000889 \| acanthosis nigricans \| 1 C0019360 \| herpes zoster infection \| 1 C0026848 \| myopathies \| 1 C0029134 \| optic neuritis \| 1 C0026986 \| myelodysplastic syndrome \| 1 C0276721 \| phaeohyphomycosis \| 1 C0032708 \| porphyria \| 1 C0020540 \| malignant hypertension \| 1 C0017665 \| membranous glomerulonephritis \| 1 C0752124 \| spinocerebellar ataxia type 6 \| 1 C0162299 \| thyroid cyst \| 1 C0002453 \| amenorrhea \| 1 C0281963 \| red cell aplasia \| 1 C0206674 \| villous adenoma \| 1 C0019348 \| herpes simplex infection \| 1 C0001175 \| acquired immune deficiency syndrome \| 1 C0034012 \| delayed puberty \| 1 C0023890 \| cirrhosis \| 1 C0024205 \| lymphadenitis \| 1 C0281658 \| intraocular lymphoma \| 1 C0032269 \| streptococcus pneumoniae infection \| 1 C0085273 \| parvovirus b19 infection \| 1 C0036202 \| sarcoidosis \| 1 C0002895 \| sickle cell disease \| 1 C0002170 \| alopecia \| 1 C0017160 \| gastroenteritis \| 1 C0026718 \| mucormycosis \| 1 C0026946 \| mycosis \| 1 C0014121 \| infective endocarditis \| 1 C0014038 \| encephalitis \| 1 C0027813 \| neuritis \| 1 C0339962 \| pulmonary mucormycosis \| 1 C0242584 \| autoimmune thrombocytopenia \| 1 C0001175 \| acquired immune deficiency syndrome (aids) \| 1 C0015458 \| parry-romberg syndrome \| 1 C0010692 \| cystitis \| 1 C0007766 \| cranial aneurysm \| 1 C0027709 \| nephrocalcinosis \| 1 C0002874 \| aplastic anaemia \| 1 C0007766 \| intracranial aneurysm \| 1 C0031099 \| periodontitis \| 1 C0206093 \| primitive neuroectodermal tumor \| 1 C0009782 \| connective tissue diseases \| 1 C1565489 \| renal insufficiency \| 1 C0024790 \| paroxysmal nocturnal hemoglobinuria \| 1 C0024894 \| mastitis \| 1 C0014868 \| esophagitis \| 1 C0021359 \| infertility \| 1 C0001126 \| renal tubular acidosis \| 1 C0042109 \| urticaria \| 1 C0041188 \| tropical pyomyositis \| 1 C0151744 \| myocardial ischemia \| 1 C0033845 \| idiopathic intracranial hypertension \| 1 C0007682 \| cns disease \| 1 C0010051 \| coronary aneurysms \| 1 C0021390 \| inflammatory bowel disease \| 1 C0004134 \| ataxia \| 1 C0033687 \| proteinuria \| 1 C0677607 \| hashimoto's thyroiditis \| 1 C0014118 \| endocarditis \| 1 C0730306 \| ocular lymphoma \| 1 C0018552 \| hamartoma \| 1 C0149530 \| congenital heart block \| 1 C0032305 \| pneumocystis carinii pneumonia \| 1 C1145670 \| respiratory failure \| 1 C0235618 \| proliferative glomerulonephritis \| 1 C0006142 \| breast cancer \| 1 C0031039 \| pericardial effusion \| 1 C0206178 \| cmv retinitis \| 1 C0029456 \| osteoporosis \| 1 C0022408 \| arthropathy \| 1 C0276088 \| escherichia coli septicemia \| 1 C0020598 \| hypoglycemia \| 1 C0020676 \| hypothyroidism \| 1 C0042900 \| vitiligo \| 1 C0007758 \| cerebellar ataxia \| 1 C0162872 \| thoracic aortic aneurysm \| 1 C0042594 \| vestibular disorders \| 1 C0012813 \| diverticulitis \| 1 C0162429 \| malnutrition \| 1 C0152966 \| pneumococcal septicaemia \| 1 C0238124 \| necrotizing fasciitis \| 1 C0238463 \| papillary thyroid carcinoma \| 1 C0010054 \| coronary atherosclerosis \| 1 C0026948 \| mycosis fungoides \| 1 C0019348 \| herpes simplex \| 1 C0042109 \| urticarial \| 1 C0023418 \| leukemia \| 1 C0041318 \| tuberculous meningitis \| 1 C0035435 \| rheumatic diseases \| 1 C0011633 \| dermatomyositis \| 1 C0002895 \| sickle-cell disease \| 1 C0043117 \| immune thrombocytopenic purpura \| 1 C0010481 \| cushing's syndrome \| 1 C0041408 \| turner syndrome \| 1 C0003486 \| aortic aneurysms \| 1 C0151436 \| leukocytoclastic vasculitis \| 1 C0038463 \| strongyloidiasis \| 1 C0085292 \| stiff-person syndrome \| 1 C0519030 \| klebsiella pneumonia \| 1 C0085278 \| anti-phospholipid antibody syndrome \| 1 C0041328 \| renal tuberculosis \| 1 C0024299 \| lymphomas \| 1 C1527336 \| sjogren syndrome \| 1 C0031090 \| periodontal disease \| 1 C0005586 \| bipolar affective disorder \| 1 C0042373 \| vascular disorder \| 1 C0037928 \| myelopathy \| 1 C0026985 \| myelodysplasia \| 1 C0021345 \| mononucleosis \| 1 C0033975 \| psychotic disorder \| 1 C0002173 \| follicular mucinosis \| 1 C0524812 \| intracranial hypotension \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:24) 11277 \| TREX1 \| UniProtKB-KW;GHR 7128 \| TNFAIP3 \| GHR 6775 \| STAT4 \| UniProtKB-KW;GHR 1493 \| CTLA4 \| UniProtKB-KW 26191 \| PTPN22 \| GHR 1401 \| CRP \| GHR 7100 \| TLR5 \| UniProtKB-KW;GHR 4058 \| LTK \| UniProtKB-KW 10125 \| RASGRP1 \| UniProtKB-KW 4688 \| NCF2 \| GHR 7292 \| TNFSF4 \| UniProtKB-KW 1380 \| CR2 \| UniProtKB-KW;GHR 3663 \| IRF5 \| UniProtKB-KW;GHR 720 \| C4A \| UniProtKB-KW;GHR 2547 \| XRCC6 \| UniProtKB-KW 2213 \| FCGR2B \| UniProtKB-KW;GHR 8737 \| RIPK1 \| GHR 3684 \| ITGAM \| UniProtKB-KW;GHR 55024 \| BANK1 \| GHR 5133 \| PDCD1 \| UniProtKB-KW;GHR 721 \| C4B \| UniProtKB-KW 1776 \| DNASE1L3 \| GHR 7520 \| XRCC5 \| UniProtKB-KW 1773 \| DNASE1 \| GHR
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:71) 712 \| C1QA \| CIPHER 720 \| C4A \| CIPHER 721 \| C4B \| CIPHER 6347 \| CCL2 \| CIPHER 6352 \| CCL5 \| CIPHER 729230 \| CCR2 \| CIPHER 1234 \| CCR5 \| CIPHER 952 \| CD38 \| CIPHER 959 \| CD40LG \| CIPHER 971 \| CD72 \| CIPHER 4261 \| CIITA \| CIPHER 1378 \| CR1 \| CIPHER 1380 \| CR2 \| CIPHER 1493 \| CTLA4 \| CIPHER 1773 \| DNASE1 \| CIPHER 1777 \| DNASE2 \| CIPHER 1786 \| DNMT1 \| CIPHER 1956 \| EGFR \| CIPHER 356 \| FASLG \| CIPHER 2204 \| FCAR \| CIPHER 2212 \| FCGR2A \| CIPHER 2213 \| FCGR2B \| CIPHER 2214 \| FCGR3A \| CIPHER 2215 \| FCGR3B \| CIPHER 55340 \| GIMAP5 \| CIPHER 3059 \| HCLS1 \| CIPHER 3105 \| HLA-A \| CIPHER 3106 \| HLA-B \| CIPHER 3107 \| HLA-C \| CIPHER 3108 \| HLA-DMA \| CIPHER 3109 \| HLA-DMB \| CIPHER 3117 \| HLA-DQA1 \| CIPHER 3119 \| HLA-DQB1 \| CIPHER 3123 \| HLA-DRB1 \| CIPHER 3306 \| HSPA2 \| CIPHER 3439 \| IFNA1 \| CIPHER 3459 \| IFNGR1 \| CIPHER 3460 \| IFNGR2 \| CIPHER 3586 \| IL10 \| CIPHER 3552 \| IL1A \| CIPHER 3557 \| IL1RN \| CIPHER 3569 \| IL6 \| CIPHER 3663 \| IRF5 \| CIPHER 3821 \| KLRC1 \| CIPHER 4049 \| LTA \| CIPHER 4153 \| MBL2 \| CIPHER 10461 \| MERTK \| CIPHER 100507436 \| MICA \| CIPHER 4277 \| MICB \| CIPHER 4282 \| MIF \| CIPHER 4846 \| NOS3 \| CIPHER 2908 \| NR3C1 \| CIPHER 22854 \| NTNG1 \| CIPHER 142 \| PARP1 \| CIPHER 5133 \| PDCD1 \| CIPHER 5743 \| PTGS2 \| CIPHER 26191 \| PTPN22 \| CIPHER 861 \| RUNX1 \| CIPHER 6583 \| SLC22A4 \| CIPHER 6696 \| SPP1 \| CIPHER 387082 \| SUMO4 \| CIPHER 6890 \| TAP1 \| CIPHER 6891 \| TAP2 \| CIPHER 7100 \| TLR5 \| CIPHER 54106 \| TLR9 \| CIPHER 7124 \| TNF \| CIPHER 23495 \| TNFRSF13B \| CIPHER 7133 \| TNFRSF1B \| CIPHER 8741 \| TNFSF13 \| CIPHER 7172 \| TPMT \| CIPHER 7297 \| TYK2 \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:517) 2 \| A2M \| 1.294 \| DISEASES 130013 \| ACMSD \| 1.011 \| DISEASES 60 \| ACTB \| 1.582 \| DISEASES 94 \| ACVRL1 \| 1.205 \| DISEASES 100 \| ADA \| 1.331 \| DISEASES 11093 \| ADAMTS13 \| 3.495 \| DISEASES 103 \| ADAR \| 1.869 \| DISEASES 79747 \| ADGB \| 2.114 \| DISEASES 9370 \| ADIPOQ \| 1.745 \| DISEASES 340351 \| AGBL3 \| 2.245 \| DISEASES 9447 \| AIM2 \| 3.359 \| DISEASES 64400 \| AKTIP \| 1.158 \| DISEASES 91526 \| ANKRD44 \| 1.993 \| DISEASES 57182 \| ANKRD50 \| 1.275 \| DISEASES 23294 \| ANKS1A \| 1.775 \| DISEASES 302 \| ANXA2 \| 2.274 \| DISEASES 55937 \| APOM \| 1.376 \| DISEASES 100505854 \| APTR \| 1.031 \| DISEASES 361 \| AQP4 \| 2.659 \| DISEASES 1388 \| ATF6B \| 1.156 \| DISEASES 9474 \| ATG5 \| 1.922 \| DISEASES 551 \| AVP \| 1.034 \| DISEASES 567 \| B2M \| 3.163 \| DISEASES 29086 \| BABAM1 \| 2.742 \| DISEASES 55024 \| BANK1 \| 4.574 \| DISEASES 57673 \| BEND3 \| 1.056 \| DISEASES 632 \| BGLAP \| 1.532 \| DISEASES 151888 \| BTLA \| 1.783 \| DISEASES 56244 \| BTNL2 \| 1.661 \| DISEASES 10917 \| BTNL3 \| 1.534 \| DISEASES 79908 \| BTNL8 \| 1.365 \| DISEASES 153579 \| BTNL9 \| 1.119 \| DISEASES 712 \| C1QA \| 3.947 \| DISEASES 714 \| C1QC \| 3.547 \| DISEASES 716 \| C1S \| 4.37 \| DISEASES 720 \| C4A \| 5.285 \| DISEASES 721 \| C4B \| 4.961 \| DISEASES 728 \| C5AR1 \| 2.278 \| DISEASES 10665 \| C6orf10 \| 1.648 \| DISEASES 773 \| CACNA1A \| 1.02 \| DISEASES 801 \| CALM1 \| 1.244 \| DISEASES 811 \| CALR \| 3.458 \| DISEASES 820 \| CAMP \| 2.055 \| DISEASES 834 \| CASP1 \| 2.886 \| DISEASES 841 \| CASP8 \| 1.971 \| DISEASES 831 \| CAST \| 1.395 \| DISEASES 339965 \| CCDC158 \| 1.09 \| DISEASES 6364 \| CCL20 \| 1.395 \| DISEASES 6349 \| CCL3L1 \| 1.737 \| DISEASES 388372 \| CCL4L1 \| 1.644 \| DISEASES 9034 \| CCRL2 \| 1.102 \| DISEASES 977 \| CD151 \| 1.284 \| DISEASES 9332 \| CD163 \| 1.766 \| DISEASES 930 \| CD19 \| 4.636 \| DISEASES 911 \| CD1C \| 2.245 \| DISEASES 912 \| CD1D \| 3.515 \| DISEASES 914 \| CD2 \| 2.202 \| DISEASES 51744 \| CD244 \| 2.88 \| DISEASES 919 \| CD247 \| 3.432 \| DISEASES 29126 \| CD274 \| 2.24 \| DISEASES 146722 \| CD300LF \| 1.967 \| DISEASES 958 \| CD40 \| 4.609 \| DISEASES 959 \| CD40LG \| 6.728 \| DISEASES 960 \| CD44 \| 2.722 \| DISEASES 962 \| CD48 \| 2.538 \| DISEASES 921 \| CD5 \| 3.803 \| DISEASES 966 \| CD59 \| 2.046 \| DISEASES 974 \| CD79B \| 1.872 \| DISEASES 9308 \| CD83 \| 2.215 \| DISEASES 942 \| CD86 \| 4.147 \| DISEASES 1038 \| CDR1 \| 4.045 \| DISEASES 1041 \| CDSN \| 5.071 \| DISEASES 1058 \| CENPA \| 1.192 \| DISEASES 1059 \| CENPB \| 3.384 \| DISEASES 401541 \| CENPP \| 1.412 \| DISEASES 55166 \| CENPQ \| 1.188 \| DISEASES 629 \| CFB \| 2.435 \| DISEASES 3075 \| CFH \| 2.01 \| DISEASES 10877 \| CFHR4 \| 1.375 \| DISEASES 3426 \| CFI \| 1.21 \| DISEASES 23274 \| CLEC16A \| 1.581 \| DISEASES 388512 \| CLEC17A \| 1.496 \| DISEASES 170482 \| CLEC4C \| 3.55 \| DISEASES 146223 \| CMTM4 \| 1.334 \| DISEASES 10695 \| CNPY3 \| 1.222 \| DISEASES 124817 \| CNTD1 \| 1.45 \| DISEASES 22796 \| COG2 \| 1.775 \| DISEASES 1308 \| COL17A1 \| 1.984 \| DISEASES 10087 \| COL4A3BP \| 1.203 \| DISEASES 1378 \| CR1 \| 4.619 \| DISEASES 1380 \| CR2 \| 2.665 \| DISEASES 1385 \| CREB1 \| 1.133 \| DISEASES 1435 \| CSF1 \| 2.386 \| DISEASES 1471 \| CST3 \| 1.126 \| DISEASES 1524 \| CX3CR1 \| 1.404 \| DISEASES 6387 \| CXCL12 \| 2.379 \| DISEASES 4283 \| CXCL9 \| 2.861 \| DISEASES 2833 \| CXCR3 \| 3.498 \| DISEASES 7852 \| CXCR4 \| 1.978 \| DISEASES 1536 \| CYBB \| 1.524 \| DISEASES 1589 \| CYP21A2 \| 1.255 \| DISEASES 1557 \| CYP2C19 \| 1.455 \| DISEASES 1565 \| CYP2D6 \| 1.681 \| DISEASES 115265 \| DDIT4L \| 1.008 \| DISEASES 51428 \| DDX41 \| 5.672 \| DISEASES 23586 \| DDX58 \| 2.133 \| DISEASES 79947 \| DHDDS \| 1.161 \| DISEASES 1660 \| DHX9 \| 1.773 \| DISEASES 8701 \| DNAH11 \| 1.674 \| DISEASES 1786 \| DNMT1 \| 3.471 \| DISEASES 1789 \| DNMT3B \| 1.444 \| DISEASES 1791 \| DNTT \| 1.437 \| DISEASES 22845 \| DOLK \| 1.173 \| DISEASES 29952 \| DPP7 \| 1.17 \| DISEASES 1805 \| DPT \| 1.072 \| DISEASES 54935 \| DUSP23 \| 1.209 \| DISEASES 1847 \| DUSP5 \| 3.12 \| DISEASES 1850 \| DUSP8 \| 1.182 \| DISEASES 1854 \| DUT \| 1.649 \| DISEASES 1781 \| DYNC1I2 \| 2.244 \| DISEASES 1906 \| EDN1 \| 1.241 \| DISEASES 163126 \| EID2 \| 1.37 \| DISEASES 953 \| ENTPD1 \| 1.107 \| DISEASES 2086 \| ERV3-1 \| 1.474 \| DISEASES 30816 \| ERVW-1 \| 2.339 \| DISEASES 2100 \| ESR2 \| 1.608 \| DISEASES 2113 \| ETS1 \| 3.103 \| DISEASES 5394 \| EXOSC10 \| 3.219 \| DISEASES 5393 \| EXOSC9 \| 1.263 \| DISEASES 346007 \| EYS \| 1.162 \| DISEASES 2160 \| F11 \| 1.598 \| DISEASES 2152 \| F3 \| 5.114 \| DISEASES 2153 \| F5 \| 1.662 \| DISEASES 2155 \| F7 \| 2.174 \| DISEASES 2157 \| F8 \| 2.852 \| DISEASES 338811 \| FAM19A2 \| 1.506 \| DISEASES 149297 \| FAM78B \| 1.088 \| DISEASES 355 \| FAS \| 3.764 \| DISEASES 356 \| FASLG \| 3.974 \| DISEASES 2205 \| FCER1A \| 1.158 \| DISEASES 2209 \| FCGR1A \| 2.905 \| DISEASES 2213 \| FCGR2B \| 5.123 \| DISEASES 2214 \| FCGR3A \| 3.486 \| DISEASES 9873 \| FCHSD2 \| 2.159 \| DISEASES 2219 \| FCN1 \| 2.475 \| DISEASES 115352 \| FCRL3 \| 3.501 \| DISEASES 2312 \| FLG \| 1.545 \| DISEASES 23768 \| FLRT2 \| 1.707 \| DISEASES 2323 \| FLT3LG \| 1.139 \| DISEASES 2290 \| FOXG1 \| 2.423 \| DISEASES 2302 \| FOXJ1 \| 1.647 \| DISEASES 50943 \| FOXP3 \| 4.823 \| DISEASES 2533 \| FYB \| 1.09 \| DISEASES 2534 \| FYN \| 1.841 \| DISEASES 10146 \| G3BP1 \| 1.788 \| DISEASES 1647 \| GADD45A \| 1.028 \| DISEASES 60674 \| GAS5 \| 1.009 \| DISEASES 2621 \| GAS6 \| 2.482 \| DISEASES 2625 \| GATA3 \| 1.876 \| DISEASES 2737 \| GLI3 \| 1.362 \| DISEASES 2800 \| GOLGA1 \| 2.048 \| DISEASES 23015 \| GOLGA8A \| 1.61 \| DISEASES 29933 \| GPR132 \| 2.3 \| DISEASES 2903 \| GRIN2A \| 2.684 \| DISEASES 2932 \| GSK3B \| 1.576 \| DISEASES 2962 \| GTF2F1 \| 1.047 \| DISEASES 2969 \| GTF2I \| 1.554 \| DISEASES 9569 \| GTF2IRD1 \| 1.889 \| DISEASES 3005 \| H1F0 \| 3.716 \| DISEASES 3035 \| HARS \| 2.22 \| DISEASES 26762 \| HAVCR1 \| 1.668 \| DISEASES 3039 \| HBA1 \| 1.297 \| DISEASES 3052 \| HCCS \| 1.115 \| DISEASES 3055 \| HCK \| 1.042 \| DISEASES 9734 \| HDAC9 \| 1.193 \| DISEASES 3009 \| HIST1H1B \| 1.359 \| DISEASES 8969 \| HIST1H2AG \| 1.331 \| DISEASES 8329 \| HIST1H2AI \| 1.331 \| DISEASES 8330 \| HIST1H2AK \| 1.201 \| DISEASES 8332 \| HIST1H2AL \| 1.331 \| DISEASES 8341 \| HIST1H2BN \| 2.272 \| DISEASES 8359 \| HIST1H4A \| 2.046 \| DISEASES 8366 \| HIST1H4B \| 2.046 \| DISEASES 8364 \| HIST1H4C \| 2.046 \| DISEASES 8360 \| HIST1H4D \| 2.045 \| DISEASES 8367 \| HIST1H4E \| 2.046 \| DISEASES 8361 \| HIST1H4F \| 2.046 \| DISEASES 8294 \| HIST1H4I \| 2.046 \| DISEASES 8363 \| HIST1H4J \| 2.046 \| DISEASES 8362 \| HIST1H4K \| 2.046 \| DISEASES 8368 \| HIST1H4L \| 2.046 \| DISEASES 8337 \| HIST2H2AA3 \| 4.898 \| DISEASES 317772 \| HIST2H2AB \| 1.304 \| DISEASES 8338 \| HIST2H2AC \| 4.898 \| DISEASES 8349 \| HIST2H2BE \| 5.025 \| DISEASES 8370 \| HIST2H4A \| 2.046 \| DISEASES 554313 \| HIST2H4B \| 2.046 \| DISEASES 128312 \| HIST3H2BB \| 1.48 \| DISEASES 121504 \| HIST4H4 \| 2.046 \| DISEASES 3105 \| HLA-A \| 3.145 \| DISEASES 3106 \| HLA-B \| 2.334 \| DISEASES 3107 \| HLA-C \| 1.095 \| DISEASES 3108 \| HLA-DMA \| 1.78 \| DISEASES 3109 \| HLA-DMB \| 1.434 \| DISEASES 3115 \| HLA-DPB1 \| 2.578 \| DISEASES 3117 \| HLA-DQA1 \| 3.244 \| DISEASES 3118 \| HLA-DQA2 \| 1.699 \| DISEASES 3119 \| HLA-DQB1 \| 2.786 \| DISEASES 3120 \| HLA-DQB2 \| 2.774 \| DISEASES 3122 \| HLA-DRA \| 1.883 \| DISEASES 3123 \| HLA-DRB1 \| 4.295 \| DISEASES 3127 \| HLA-DRB5 \| 2.996 \| DISEASES 3135 \| HLA-G \| 1.976 \| DISEASES 3146 \| HMGB1 \| 3.033 \| DISEASES 3151 \| HMGN2 \| 2.687 \| DISEASES 3178 \| HNRNPA1 \| 1.42 \| DISEASES 3181 \| HNRNPA2B1 \| 2.51 \| DISEASES 220988 \| HNRNPA3 \| 1.138 \| DISEASES 3240 \| HP \| 2.021 \| DISEASES 3320 \| HSP90AA1 \| 2.257 \| DISEASES 3326 \| HSP90AB1 \| 1.634 \| DISEASES 51182 \| HSPA14 \| 1.162 \| DISEASES 3329 \| HSPD1 \| 3.001 \| DISEASES 3339 \| HSPG2 \| 3.827 \| DISEASES 3360 \| HTR4 \| 1.217 \| DISEASES 3386 \| ICAM4 \| 1.252 \| DISEASES 23308 \| ICOSLG \| 2.402 \| DISEASES 414328 \| IDNK \| 2.054 \| DISEASES 3428 \| IFI16 \| 2.783 \| DISEASES 10561 \| IFI44 \| 2.085 \| DISEASES 10964 \| IFI44L \| 2.995 \| DISEASES 2537 \| IFI6 \| 1.547 \| DISEASES 3434 \| IFIT1 \| 2.889 \| DISEASES 3437 \| IFIT3 \| 1.849 \| DISEASES 3451 \| IFNA17 \| 2.321 \| DISEASES 3440 \| IFNA2 \| 2.023 \| DISEASES 3455 \| IFNAR2 \| 2.179 \| DISEASES 3456 \| IFNB1 \| 3.202 \| DISEASES 3459 \| IFNGR1 \| 1.15 \| DISEASES 10320 \| IKZF1 \| 2.948 \| DISEASES 22806 \| IKZF3 \| 2.264 \| DISEASES 3586 \| IL10 \| 5.31 \| DISEASES 3594 \| IL12RB1 \| 1.399 \| DISEASES 3605 \| IL17A \| 4.784 \| DISEASES 112744 \| IL17F \| 2.001 \| DISEASES 29949 \| IL19 \| 1.426 \| DISEASES 84639 \| IL1F10 \| 1.604 \| DISEASES 50615 \| IL21R \| 2.788 \| DISEASES 50616 \| IL22 \| 2.105 \| DISEASES 149233 \| IL23R \| 1.742 \| DISEASES 3559 \| IL2RA \| 2.649 \| DISEASES 133396 \| IL31RA \| 3.8 \| DISEASES 90865 \| IL33 \| 1.402 \| DISEASES 3563 \| IL3RA \| 3.584 \| DISEASES 3608 \| ILF2 \| 1.809 \| DISEASES 3609 \| ILF3 \| 1.301 \| DISEASES 3635 \| INPP5D \| 1.86 \| DISEASES 3654 \| IRAK1 \| 3.118 \| DISEASES 51135 \| IRAK4 \| 2.474 \| DISEASES 3660 \| IRF2 \| 1.23 \| DISEASES 3662 \| IRF4 \| 2.711 \| DISEASES 3663 \| IRF5 \| 5.738 \| DISEASES 3665 \| IRF7 \| 3.77 \| DISEASES 10379 \| IRF9 \| 1.458 \| DISEASES 9636 \| ISG15 \| 2.844 \| DISEASES 3683 \| ITGAL \| 3.442 \| DISEASES 3684 \| ITGAM \| 3.853 \| DISEASES 3716 \| JAK1 \| 1.589 \| DISEASES 3717 \| JAK2 \| 1.033 \| DISEASES 3725 \| JUN \| 1.595 \| DISEASES 10945 \| KDELR1 \| 1.056 \| DISEASES 23240 \| KIAA0922 \| 1.334 \| DISEASES 3798 \| KIF5A \| 1.424 \| DISEASES 3802 \| KIR2DL1 \| 2.061 \| DISEASES 3803 \| KIR2DL2 \| 1.795 \| DISEASES 3804 \| KIR2DL3 \| 1.841 \| DISEASES 3805 \| KIR2DL4 \| 1.716 \| DISEASES 59349 \| KLHL12 \| 1.699 \| DISEASES 55975 \| KLHL7 \| 1.162 \| DISEASES 9622 \| KLK4 \| 1.991 \| DISEASES 3821 \| KLRC1 \| 1.996 \| DISEASES 3822 \| KLRC2 \| 2.315 \| DISEASES 3824 \| KLRD1 \| 1.563 \| DISEASES 3841 \| KPNA5 \| 1.439 \| DISEASES 3895 \| KTN1 \| 1.039 \| DISEASES 3903 \| LAIR1 \| 2.779 \| DISEASES 3916 \| LAMP1 \| 1.769 \| DISEASES 27040 \| LAT \| 1.247 \| DISEASES 81606 \| LBH \| 2.254 \| DISEASES 3932 \| LCK \| 2.654 \| DISEASES 84247 \| LDOC1L \| 1.243 \| DISEASES 3965 \| LGALS9 \| 1.743 \| DISEASES 101927624 \| LINC01150 \| 1.52 \| DISEASES 100885779 \| LINC-ROR \| 1.07 \| DISEASES 25802 \| LMOD1 \| 1.302 \| DISEASES 4018 \| LPA \| 1.741 \| DISEASES 474354 \| LRRC18 \| 2.245 \| DISEASES 55222 \| LRRC20 \| 2.026 \| DISEASES 4049 \| LTA \| 2.624 \| DISEASES 4063 \| LY9 \| 3.406 \| DISEASES 4067 \| LYN \| 3.692 \| DISEASES 388695 \| LYSMD1 \| 2.087 \| DISEASES 4113 \| MAGEB2 \| 1.198 \| DISEASES 11184 \| MAP4K1 \| 1.235 \| DISEASES 5599 \| MAPK8 \| 1.82 \| DISEASES 10747 \| MASP2 \| 2.169 \| DISEASES 57506 \| MAVS \| 2.074 \| DISEASES 115004 \| MB21D1 \| 1.726 \| DISEASES 4153 \| MBL2 \| 3.411 \| DISEASES 4155 \| MBP \| 1.806 \| DISEASES 161357 \| MDGA2 \| 1.733 \| DISEASES 23195 \| MDN1 \| 1.054 \| DISEASES 4204 \| MECP2 \| 2.289 \| DISEASES 79104 \| MEG8 \| 1.175 \| DISEASES 100507436 \| MICA \| 1.78 \| DISEASES 407975 \| MIR17HG \| 1.002 \| DISEASES 4318 \| MMP9 \| 2.249 \| DISEASES 4332 \| MNDA \| 2.492 \| DISEASES 4340 \| MOG \| 1.004 \| DISEASES 4439 \| MSH5 \| 1.745 \| DISEASES 4524 \| MTHFR \| 1.892 \| DISEASES 8897 \| MTMR3 \| 1.97 \| DISEASES 2475 \| MTOR \| 2.002 \| DISEASES 4599 \| MX1 \| 3.801 \| DISEASES 4602 \| MYB \| 1.474 \| DISEASES 4609 \| MYC \| 1.623 \| DISEASES 4615 \| MYD88 \| 3.057 \| DISEASES 4650 \| MYO9B \| 1.321 \| DISEASES 4688 \| NCF2 \| 2.135 \| DISEASES 9436 \| NCR2 \| 1.122 \| DISEASES 4772 \| NFATC1 \| 1.092 \| DISEASES 4773 \| NFATC2 \| 1.895 \| DISEASES 4803 \| NGF \| 1.411 \| DISEASES 54475 \| NLE1 \| 2.694 \| DISEASES 22861 \| NLRP1 \| 2.133 \| DISEASES 114548 \| NLRP3 \| 2.615 \| DISEASES 4843 \| NOS2 \| 1.043 \| DISEASES 4868 \| NPHS1 \| 1.471 \| DISEASES 7827 \| NPHS2 \| 1.386 \| DISEASES 4938 \| OAS1 \| 2.576 \| DISEASES 4939 \| OAS2 \| 2.028 \| DISEASES 4942 \| OAT \| 1.334 \| DISEASES 4948 \| OCA2 \| 3.461 \| DISEASES 338662 \| OR8D4 \| 2.026 \| DISEASES 5027 \| P2RX7 \| 1.253 \| DISEASES 23569 \| PADI4 \| 2.793 \| DISEASES 142 \| PARP1 \| 1.542 \| DISEASES 64098 \| PARVG \| 1.01 \| DISEASES 5087 \| PBX1 \| 1.624 \| DISEASES 5133 \| PDCD1 \| 3.874 \| DISEASES 80380 \| PDCD1LG2 \| 1.232 \| DISEASES 5143 \| PDE4C \| 1.367 \| DISEASES 57162 \| PELI1 \| 1.451 \| DISEASES 5236 \| PGM1 \| 1.182 \| DISEASES 5238 \| PGM3 \| 1.277 \| DISEASES 57649 \| PHF12 \| 1.11 \| DISEASES 57661 \| PHRF1 \| 3.359 \| DISEASES 54872 \| PIGG \| 2.123 \| DISEASES 93183 \| PIGM \| 1.358 \| DISEASES 23556 \| PIGN \| 1.35 \| DISEASES 5293 \| PIK3CD \| 1.404 \| DISEASES 5294 \| PIK3CG \| 1.852 \| DISEASES 79837 \| PIP4K2C \| 1.421 \| DISEASES 59339 \| PLEKHA2 \| 1.168 \| DISEASES 79666 \| PLEKHF2 \| 1.176 \| DISEASES 5359 \| PLSCR1 \| 1.798 \| DISEASES 29944 \| PNMA3 \| 2.121 \| DISEASES 10623 \| POLR3C \| 1.397 \| DISEASES 5515 \| PPP2CA \| 2.516 \| DISEASES 639 \| PRDM1 \| 2.638 \| DISEASES 56980 \| PRDM10 \| 1.162 \| DISEASES 5580 \| PRKCD \| 1.475 \| DISEASES 5618 \| PRLR \| 2.455 \| DISEASES 5627 \| PROS1 \| 1.642 \| DISEASES 11168 \| PSIP1 \| 2.246 \| DISEASES 5696 \| PSMB8 \| 1.428 \| DISEASES 5743 \| PTGS2 \| 1.423 \| DISEASES 2185 \| PTK2B \| 1.468 \| DISEASES 26191 \| PTPN22 \| 4.631 \| DISEASES 5788 \| PTPRC \| 3.133 \| DISEASES 54899 \| PXK \| 3.832 \| DISEASES 11264 \| PXMP4 \| 1.125 \| DISEASES 149628 \| PYHIN1 \| 2.864 \| DISEASES 5867 \| RAB4A \| 3.478 \| DISEASES 25780 \| RASGRP3 \| 1.583 \| DISEASES 55225 \| RAVER2 \| 1.269 \| DISEASES 27316 \| RBMX \| 2.355 \| DISEASES 54542 \| RC3H2 \| 2.343 \| DISEASES 440163 \| RNASE13 \| 1.2 \| DISEASES 79621 \| RNASEH2B \| 1.683 \| DISEASES 7732 \| RNF112 \| 2.003 \| DISEASES 91445 \| RNF185 \| 1.498 \| DISEASES 6086 \| RNY4 \| 1.717 \| DISEASES 6097 \| RORC \| 1.253 \| DISEASES 80135 \| RPF1 \| 1.737 \| DISEASES 6129 \| RPL7 \| 2.499 \| DISEASES 79897 \| RPP21 \| 1.214 \| DISEASES 6187 \| RPS2 \| 3.183 \| DISEASES 6224 \| RPS20 \| 1.048 \| DISEASES 6280 \| S100A9 \| 1.48 \| DISEASES 6288 \| SAA1 \| 1.974 \| DISEASES 1757 \| SARDH \| 3.052 \| DISEASES 9728 \| SECISBP2L \| 1.173 \| DISEASES 6401 \| SELE \| 3.397 \| DISEASES 5265 \| SERPINA1 \| 2.531 \| DISEASES 1992 \| SERPINB1 \| 1.689 \| DISEASES 5271 \| SERPINB8 \| 1.588 \| DISEASES 462 \| SERPINC1 \| 3.842 \| DISEASES 5345 \| SERPINF2 \| 2.703 \| DISEASES 7536 \| SF1 \| 1.184 \| DISEASES 4068 \| SH2D1A \| 1.365 \| DISEASES 117157 \| SH2D1B \| 1.554 \| DISEASES 9047 \| SH2D2A \| 1.331 \| DISEASES 59307 \| SIGIRR \| 2.745 \| DISEASES 6614 \| SIGLEC1 \| 3.016 \| DISEASES 8778 \| SIGLEC5 \| 1.501 \| DISEASES 114836 \| SLAMF6 \| 3.83 \| DISEASES 57823 \| SLAMF7 \| 2.288 \| DISEASES 6520 \| SLC3A2 \| 2.039 \| DISEASES 9748 \| SLK \| 4.106 \| DISEASES 9887 \| SMG7 \| 1.767 \| DISEASES 23583 \| SMUG1 \| 1.43 \| DISEASES 26770 \| SNORD79 \| 1.716 \| DISEASES 6625 \| SNRNP70 \| 5.97 \| DISEASES 6628 \| SNRPB \| 3.532 \| DISEASES 8651 \| SOCS1 \| 2.163 \| DISEASES 9021 \| SOCS3 \| 1.126 \| DISEASES 10580 \| SORBS1 \| 1.661 \| DISEASES 6667 \| SP1 \| 1.337 \| DISEASES 6672 \| SP100 \| 1.659 \| DISEASES 145946 \| SPATA8 \| 2.08 \| DISEASES 26010 \| SPATS2L \| 1.002 \| DISEASES 6693 \| SPN \| 1.964 \| DISEASES 6696 \| SPP1 \| 2.779 \| DISEASES 6709 \| SPTAN1 \| 3.171 \| DISEASES 6714 \| SRC \| 1.675 \| DISEASES 6430 \| SRSF5 \| 2.178 \| DISEASES 10274 \| STAG1 \| 1.452 \| DISEASES 6772 \| STAT1 \| 3.598 \| DISEASES 6775 \| STAT4 \| 4.931 \| DISEASES 6776 \| STAT5A \| 1.509 \| DISEASES 29966 \| STRN3 \| 1.029 \| DISEASES 6818 \| SULT1A3 \| 2.977 \| DISEASES 445329 \| SULT1A4 \| 3.002 \| DISEASES 6850 \| SYK \| 3.679 \| DISEASES 11346 \| SYNPO \| 1.39 \| DISEASES 80222 \| TARS2 \| 1.979 \| DISEASES 123283 \| TARSL2 \| 2.016 \| DISEASES 29110 \| TBK1 \| 1.543 \| DISEASES 6932 \| TCF7 \| 2.251 \| DISEASES 54790 \| TET2 \| 1.24 \| DISEASES 200424 \| TET3 \| 1.265 \| DISEASES 7018 \| TF \| 1.81 \| DISEASES 7037 \| TFRC \| 2.076 \| DISEASES 7042 \| TGFB2 \| 1.188 \| DISEASES 7052 \| TGM2 \| 1.306 \| DISEASES 7056 \| THBD \| 3.707 \| DISEASES 102659353 \| THRIL \| 1.017 \| DISEASES 7072 \| TIA1 \| 1.57 \| DISEASES 201633 \| TIGIT \| 1.749 \| DISEASES 114609 \| TIRAP \| 1.029 \| DISEASES 7099 \| TLR4 \| 3.481 \| DISEASES 7100 \| TLR5 \| 4.932 \| DISEASES 51284 \| TLR7 \| 5.752 \| DISEASES 54106 \| TLR9 \| 5.616 \| DISEASES 340061 \| TMEM173 \| 2.488 \| DISEASES 8269 \| TMEM187 \| 2.425 \| DISEASES 55254 \| TMEM39A \| 3.15 \| DISEASES 7124 \| TNF \| 5.599 \| DISEASES 51330 \| TNFRSF12A \| 3.082 \| DISEASES 8784 \| TNFRSF18 \| 2.67 \| DISEASES 7133 \| TNFRSF1B \| 4.229 \| DISEASES 8718 \| TNFRSF25 \| 5.11 \| DISEASES 7293 \| TNFRSF4 \| 2.68 \| DISEASES 8771 \| TNFRSF6B \| 1.561 \| DISEASES 3604 \| TNFRSF9 \| 2.133 \| DISEASES 8742 \| TNFSF12 \| 3.85 \| DISEASES 8741 \| TNFSF13 \| 2.047 \| DISEASES 10673 \| TNFSF13B \| 6.438 \| DISEASES 79155 \| TNIP2 \| 1.397 \| DISEASES 27327 \| TNRC6A \| 2.087 \| DISEASES 7148 \| TNXB \| 1.857 \| DISEASES 7150 \| TOP1 \| 3.302 \| DISEASES 1861 \| TOR1A \| 2.52 \| DISEASES 7158 \| TP53BP1 \| 1.381 \| DISEASES 8717 \| TRADD \| 1.24 \| DISEASES 7185 \| TRAF1 \| 2.534 \| DISEASES 10758 \| TRAF3IP2 \| 1.724 \| DISEASES 7189 \| TRAF6 \| 2.308 \| DISEASES 285852 \| TREML4 \| 1.315 \| DISEASES 11277 \| TREX1 \| 4.927 \| DISEASES 51499 \| TRIAP1 \| 6.07 \| DISEASES 10346 \| TRIM22 \| 1.156 \| DISEASES 57093 \| TRIM49 \| 2.08 \| DISEASES 85363 \| TRIM5 \| 1.075 \| DISEASES 140691 \| TRIM69 \| 1.112 \| DISEASES 6738 \| TROVE2 \| 5.715 \| DISEASES 64061 \| TSPYL2 \| 1.089 \| DISEASES 100287898 \| TTC34 \| 1.374 \| DISEASES 7332 \| UBE2L3 \| 3.1 \| DISEASES 130507 \| UBR3 \| 1.157 \| DISEASES 373856 \| USP41 \| 2.026 \| DISEASES 10090 \| UST \| 1.569 \| DISEASES 7409 \| VAV1 \| 1.851 \| DISEASES 7421 \| VDR \| 3.064 \| DISEASES 7422 \| VEGFA \| 1.989 \| DISEASES 7441 \| VPREB1 \| 1.059 \| DISEASES 57705 \| WDFY4 \| 3.618 \| DISEASES 23038 \| WDTC1 \| 1.66 \| DISEASES 147179 \| WIPF2 \| 1.557 \| DISEASES 286046 \| XKR6 \| 2.542 \| DISEASES 7520 \| XRCC5 \| 1.648 \| DISEASES 2547 \| XRCC6 \| 1.764 \| DISEASES 25844 \| YIPF3 \| 1.114 \| DISEASES 57621 \| ZBTB2 \| 1.064 \| DISEASES 79842 \| ZBTB3 \| 1.33 \| DISEASES 124626 \| ZPBP2 \| 1.329 \| DISEASES
Locus	(Waiting for update.)

Disease ID	804
Disease	lupus erythematosus
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:262) HP:0000123 \| Nephritis \| 33 HP:0002621 \| Atherosclerosis \| 30 HP:0002633 \| Vasculitis \| 18 HP:0003613 \| Antiphospholipid antibodies \| 17 HP:0001873 \| Low platelet count \| 16 HP:0000822 \| Hypertension \| 11 HP:0001369 \| Arthritis \| 11 HP:0002960 \| Autoimmune condition \| 11 HP:0000099 \| Glomerular nephritis \| 10 HP:0000979 \| Purpura \| 10 HP:0002617 \| Aneurysmal dilatation \| 10 HP:0001903 \| Anemia \| 10 HP:0012378 \| Fatigue \| 10 HP:0010885 \| Aseptic necrosis \| 9 HP:0000709 \| Psychosis \| 9 HP:0001297 \| Cerebral vascular events \| 8 HP:0000716 \| Depression \| 8 HP:0001658 \| Myocardial infarction \| 6 HP:0003473 \| Fatigable weakness \| 6 HP:0000855 \| Insulin resistance \| 6 HP:0100614 \| Muscle inflammation \| 6 HP:0002092 \| Pulmonary artery hypertension \| 6 HP:0000112 \| Nephropathy \| 6 HP:0001298 \| Encephalopathy \| 5 HP:0002665 \| Lymphoma \| 5 HP:0002721 \| Immunodeficiency \| 5 HP:0002315 \| Headaches \| 5 HP:0003761 \| Calcinosis \| 5 HP:0000992 \| Skin photosensitivity \| 5 HP:0000488 \| Noninflammatory retina disease \| 4 HP:0001915 \| Aplastic anemia \| 4 HP:0000739 \| Anxiety \| 4 HP:0002090 \| Pneumonia \| 4 HP:0002860 \| Squamous cell carcinoma \| 4 HP:0001875 \| Neutropenia \| 4 HP:0001733 \| Pancreatic inflammation \| 4 HP:0012531 \| Pain \| 4 HP:0004389 \| Intestinal pseudo-obstruction \| 4 HP:0002664 \| Neoplasia \| 4 HP:0000708 \| Behavioral problems \| 4 HP:0002725 \| Systemic lupus erythematosus \| 4 HP:0001370 \| Rheumatoid arthritis \| 4 HP:0100512 \| Vitamin D deficiency \| 3 HP:0002027 \| Abdominal pain \| 3 HP:0100543 \| Cognitive deficits \| 3 HP:0004416 \| Precocious atherosclerosis \| 3 HP:0012115 \| Liver inflammation \| 3 HP:0000752 \| Hyperactive behavior \| 3 HP:0004942 \| Aortic aneurysm \| 3 HP:0000969 \| Dropsy \| 3 HP:0100280 \| Morbus Crohn \| 3 HP:0100658 \| Bacterial infection of skin \| 3 HP:0001888 \| Lymphocytopenia \| 3 HP:0002352 \| Leukoencephalopathy \| 3 HP:0009830 \| Peripheral neuritis \| 3 HP:0002102 \| Pleuritis \| 3 HP:0000820 \| Thyroid abnormality \| 3 HP:0002243 \| Protein-losing enteropathy \| 3 HP:0000083 \| Renal insufficiency \| 3 HP:0011974 \| Myelofibrosis \| 3 HP:0030731 \| Carcinoma \| 3 HP:0002202 \| Pleural effusion \| 3 HP:0002242 \| Enteropathy \| 3 HP:0030880 \| Raynaud phenomenon \| 3 HP:0001677 \| Coronary artery disease \| 3 HP:0001735 \| Acute pancreatitis \| 3 HP:0100550 \| Rupture of tendons \| 3 HP:0000819 \| Diabetes mellitus \| 3 HP:0000572 \| Visual loss \| 3 HP:0006510 \| Chronic obstructive pulmonary disease \| 2 HP:0004944 \| Cerebral artery aneurysm \| 2 HP:0100522 \| Thymoma \| 2 HP:0001701 \| Pericarditis \| 2 HP:0100699 \| Scarring \| 2 HP:0002459 \| Dysautonomia \| 2 HP:0001878 \| Haemolytic anaemia \| 2 HP:0006775 \| Multiple myeloma \| 2 HP:0002140 \| Ischemic stroke \| 2 HP:0002099 \| Asthma \| 2 HP:0001287 \| Meningitis \| 2 HP:0004431 \| Complement deficiency \| 2 HP:0012622 \| Chronic kidney disease \| 2 HP:0001659 \| Aortic insufficiency \| 2 HP:0001907 \| Thromboembolic disease \| 2 HP:0100324 \| Progressive systemic scleroderma \| 2 HP:0003765 \| Psoriasis \| 2 HP:0002354 \| Memory loss \| 2 HP:0000100 \| Nephrosis \| 2 HP:0006530 \| Interstitial lung disease \| 2 HP:0004859 \| Amegakaryocytic thrombocytopenia \| 2 HP:0010702 \| Hypergammaglobulinaemia \| 2 HP:0000821 \| Underactive thyroid \| 2 HP:0002076 \| Migraine headaches \| 2 HP:0004950 \| Peripheral artery disease \| 2 HP:0012490 \| Inflammation of fat tissue \| 2 HP:0100665 \| Angiooedema \| 2 HP:0001945 \| Fever \| 2 HP:0007417 \| Discoid lupus erythematosus \| 2 HP:0002583 \| Colitis \| 2 HP:0000490 \| Sunken eyes \| 2 HP:0002863 \| Myelodysplastic syndrome \| 2 HP:0001250 \| Seizures \| 2 HP:0003774 \| End-stage renal failure \| 2 HP:0045073 \| Serositis \| 2 HP:0012410 \| Pure red cell aplasia \| 2 HP:0002720 \| Decreased immunoglobulin A \| 2 HP:0005523 \| Lymphoproliferative disorder \| 2 HP:0100806 \| Sepsis \| 2 HP:0002516 \| Intracranial pressure elevation \| 2 HP:0012486 \| Inflammation of spinal cord \| 2 HP:0002107 \| Collapsed lung \| 2 HP:0001635 \| Congestive heart failure \| 1 HP:0000141 \| Abnormal absence of menstruation \| 1 HP:0012579 \| Minimal change glomerulonephritis \| 1 HP:0007302 \| Bipolar disorder \| 1 HP:0002500 \| Leukoaraiosis \| 1 HP:0002910 \| Elevated transaminases \| 1 HP:0011675 \| Arrhythmias \| 1 HP:0006859 \| Posterior leukoencephalopathy \| 1 HP:0100539 \| Periorbital swelling \| 1 HP:0000096 \| Glomerulosclerosis \| 1 HP:0001061 \| Acne \| 1 HP:0100718 \| Uterine rupture \| 1 HP:0100653 \| Optic neuritis \| 1 HP:0000956 \| Keratosis nigricans \| 1 HP:0002605 \| Hepatic necrosis \| 1 HP:0012344 \| Morphea \| 1 HP:0001289 \| Confusion \| 1 HP:0003095 \| Septic arthritis \| 1 HP:0002890 \| Thyroid carcinoma \| 1 HP:0001909 \| Leukemia \| 1 HP:0012588 \| Steroid-resistant nephrotic syndrome \| 1 HP:0012223 \| Ruptured spleen \| 1 HP:0005305 \| Cerebral vein thrombosis \| 1 HP:0100532 \| Scleritis \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0007380 \| Facial telangiectatic vessels \| 1 HP:0000790 \| Hematuria \| 1 HP:0002514 \| Intracranial calcifications \| 1 HP:0012722 \| Heart block \| 1 HP:0001890 \| Autoimmune hemolytic anemia \| 1 HP:0012075 \| Personality disorder \| 1 HP:0000501 \| Glaucoma \| 1 HP:0002232 \| Patchy alopecia \| 1 HP:0012133 \| Erythroid hypoplasia \| 1 HP:0000963 \| Thin skin \| 1 HP:0200029 \| Cutaneous vasculitis \| 1 HP:0007018 \| Attention deficits \| 1 HP:0011695 \| Cerebellar hemorrhage \| 1 HP:0001663 \| Ventricular fibrillation \| 1 HP:0000843 \| Hyperparathyroidism \| 1 HP:0010280 \| Stomatitis \| 1 HP:0001581 \| Recurrent skin infections \| 1 HP:0011450 \| CNS infection \| 1 HP:0002206 \| Pulmonary fibrosis \| 1 HP:0000939 \| Osteoporosis \| 1 HP:0001279 \| Syncope \| 1 HP:0002093 \| progressive respiratory failure \| 1 HP:0001045 \| Blotchy loss of skin color \| 1 HP:0000938 \| Decreased bone mineral density \| 1 HP:0012641 \| Decreased intracranial pressure \| 1 HP:0002138 \| Subarachnoid hemorrhage \| 1 HP:0002729 \| Follicular hyperplasia \| 1 HP:0002204 \| Pulmonary embolism \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0011096 \| Demyelination \| 1 HP:0002133 \| Status epilepticus \| 1 HP:0011900 \| Hypofibrinogenemia \| 1 HP:0001943 \| Hypoglycemia \| 1 HP:0002273 \| Tetraparesis \| 1 HP:0012156 \| Hemophagocytosis \| 1 HP:0030065 \| Primitive neuroectodermal tumor \| 1 HP:0000651 \| Diplopia \| 1 HP:0002829 \| Arthralgias \| 1 HP:0002634 \| Arteriosclerosis \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0100607 \| Painful menstruation \| 1 HP:0001596 \| Hair loss \| 1 HP:0001025 \| Hives \| 1 HP:0000121 \| Nephrocalcinosis \| 1 HP:0005942 \| Desquamative interstitial pneumonitis \| 1 HP:0003073 \| Hypoalbuminaemia \| 1 HP:0200043 \| Verrucae \| 1 HP:0000789 \| Infertility \| 1 HP:0004395 \| Malnutrition \| 1 HP:0100033 \| Tic disorder \| 1 HP:0002922 \| Increased CSF protein \| 1 HP:0200034 \| Papule \| 1 HP:0001947 \| Renal tubular acidosis \| 1 HP:0001928 \| Abnormal blood coagulation studies \| 1 HP:0002383 \| Encephalitis \| 1 HP:0100758 \| Gangrene \| 1 HP:0100633 \| Inflammation of the esophagus \| 1 HP:0030692 \| Brain tumor \| 1 HP:0002895 \| Papillary thyroid carcinoma \| 1 HP:0007544 \| Piebaldism \| 1 HP:0001751 \| Vestibular dysfunction \| 1 HP:0000867 \| Secondary hyperparathyroidism \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0001251 \| Ataxia \| 1 HP:0000704 \| Pyorrhea \| 1 HP:0011944 \| Small vessel vasculitis \| 1 HP:0003470 \| Inability to move \| 1 HP:0012281 \| Chylous ascites \| 1 HP:0002907 \| Microhematuria \| 1 HP:0000407 \| sensorineural hearing loss \| 1 HP:0003201 \| Rhabdomyolysis \| 1 HP:0003198 \| Myopathic changes \| 1 HP:0000823 \| Pubertal delay \| 1 HP:0012578 \| Membranous glomerulonephritis \| 1 HP:0001541 \| Ascites \| 1 HP:0012727 \| Thoracic aortic aneurysm \| 1 HP:0100825 \| Inflammation of the lips \| 1 HP:0004326 \| Cachexia \| 1 HP:0100646 \| Thyroiditis \| 1 HP:0100584 \| Endocarditis \| 1 HP:0012740 \| Papilloma \| 1 HP:0000126 \| Hydronephrosis \| 1 HP:0001698 \| Pericardial effusions \| 1 HP:0002647 \| Aortic dissection \| 1 HP:0030350 \| Erythematous papule \| 1 HP:0003040 \| Arthropathy \| 1 HP:0002840 \| Lymphadenitis \| 1 HP:0001324 \| Muscular weakness \| 1 HP:0001047 \| Atopic dermatitis \| 1 HP:0004943 \| Accelerated atherosclerosis \| 1 HP:0010302 \| Tumor of the spinal cord \| 1 HP:0001300 \| Parkinsonism \| 1 HP:0004818 \| Paroxysmal nocturnal hemoglobinuria \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0030882 \| Enlargement of the diameter (cross-section) of a coronary artery. \| 1 HP:0100310 \| Extradural hematoma \| 1 HP:0030069 \| Primary central nervous system lymphoma \| 1 HP:0012089 \| Arteritis \| 1 HP:0001973 \| Autoimmune thrombocytopenia \| 1 HP:0000656 \| Ectropion \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0000872 \| Hashimoto's thyroiditis \| 1 HP:0000829 \| Hypoparathyroidism \| 1 HP:0003641 \| Hemoglobin in urine \| 1 HP:0002615 \| Low blood pressure \| 1 HP:0006689 \| Bacterial endocarditis \| 1 HP:0002072 \| Chorea \| 1 HP:0012636 \| Retinal vein occlusion \| 1 HP:0002196 \| Myelopathy \| 1 HP:0006824 \| Cranial nerve palsy \| 1 HP:0030127 \| Endometriosis \| 1 HP:0003493 \| Elevated antinuclear antibody \| 1 HP:0002170 \| Intracranial hemorrhage \| 1 HP:0000097 \| focal glomerulosclerosis \| 1 HP:0004929 \| Coronary artherosclerosis \| 1 HP:0000093 \| Proteinuria \| 1 HP:0012191 \| B-cell lymphoma \| 1 HP:0002716 \| Lymph node hyperplasia \| 1 HP:0010566 \| Hamartoma \| 1 HP:0006515 \| Interstitial pneumonitis \| 1 HP:0005206 \| Pancreatic pseudocyst \| 1 HP:0100754 \| Mania \| 1 HP:0100578 \| Lipoatrophy \| 1 HP:0004936 \| Blood clot in vein \| 1 HP:0001622 \| Premature delivery \| 1 HP:0012190 \| T cell lymphoma \| 1

Disease ID	804
Disease	lupus erythematosus
Manually Symptom	UMLS \| Name(Total Manually Symptoms:79) C2364133 \| infection C2364072 \| depression C2186740 \| urticaria C2046121 \| aortic dissection C1963220 \| pulmonary hypertension C1963211 \| pericarditis C1963138 \| hypertension C1962971 \| myocarditis C1868885 \| uncontrolled hypertension C1705714 \| warts C1403411 \| lymphadenosis cutis benigna C1402315 \| vascular lesions C1253937 \| pericardial effusion C1000483 \| anemia C0857305 \| thrombocytopenic purpura C0743711 \| eye lesion C0742115 \| cerebritis C0393799 \| miller-fisher syndrome C0376293 \| stigmata C0272242 \| complement deficiency C0265145 \| chronic pericarditis with effusion C0263390 \| papular mucinosis C0263367 \| koebner phenomenon C0262988 \| cutaneous vasculitis C0242666 \| protein s deficiency C0234962 \| pulmonary vasculitis C0234906 \| annular erythema C0233401 \| psychiatric symptom C0221011 \| malignant atrophic papulosis C0162855 \| mucinosis C0155773 \| portal vein thrombosis C0151205 \| periorbital edema C0085932 \| bullous skin disease C0085636 \| light sensitivity C0042900 \| vitiligo C0042373 \| vascular disorders C0041327 \| pulmonary tuberculosis C0040053 \| thrombosis C0040034 \| thrombocytopenia C0037285 \| skin manifestations C0037284 \| skin lesions C0037284 \| skin lesion C0037274 \| skin disease C0033975 \| psychosis C0033774 \| pruritus C0032453 \| relapsing polychondritis C0031736 \| polymorphous light eruption C0031048 \| constrictive pericarditis C0030326 \| panniculitis C0029166 \| oral manifestations C0029118 \| opportunistic infection C0027726 \| nephrotic syndrome C0027697 \| nephritis C0027051 \| myocardial infarction C0026848 \| myopathy C0024312 \| lymphocytopenia C0023223 \| leg ulcers C0022658 \| renal disease C0022658 \| nephropathy C0022408 \| arthropathy C0019829 \| malignant lymphogranulomatosis C0019080 \| hemorrhage C0018784 \| sensorineural hearing loss C0017658 \| glomerulonephritis C0017181 \| gastrointestinal hemorrhage C0017086 \| gangrene C0016436 \| folliculitides C0016085 \| filariasis C0016053 \| fibromyalgia C0015458 \| progressive hemifacial atrophy C0015230 \| rash C0013182 \| drug hypersensitivity C0012739 \| disseminated intravascular coagulation C0007114 \| cancer of the skin C0006840 \| moniliasis C0005779 \| coagulation disorder C0004610 \| bacteremia C0002880 \| autoimmune hemolytic anemia C0002171 \| alopecia areata
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:42) C0009450 \| infection \| 34 C0027697 \| nephritis \| 33 C0040034 \| thrombocytopenia \| 16 C0020538 \| hypertension \| 11 C0019080 \| hemorrhage \| 11 C0022658 \| renal disease \| 11 C0017658 \| glomerulonephritis \| 10 C0033975 \| psychosis \| 9 C0040053 \| thrombosis \| 9 C0034153 \| thrombocytopenic purpura \| 9 C0011570 \| depression \| 8 C0002871 \| anemia \| 6 C0022658 \| nephropathy \| 6 C0233401 \| psychiatric symptom \| 6 C0027051 \| myocardial infarction \| 6 C0020542 \| pulmonary hypertension \| 6 C0162855 \| mucinosis \| 5 C0037284 \| skin lesion \| 5 C0037284 \| skin lesions \| 4 C0015230 \| rash \| 3 C0037285 \| skin manifestations \| 2 C0030326 \| panniculitis \| 2 C0027726 \| nephrotic syndrome \| 2 C0272242 \| complement deficiency \| 2 C0031046 \| pericarditis \| 2 C0262988 \| cutaneous vasculitis \| 1 C0263367 \| koebner phenomenon \| 1 C0017086 \| gangrene \| 1 C0031039 \| pericardial effusion \| 1 C0002880 \| autoimmune hemolytic anemia \| 1 C1402315 \| vascular lesions \| 1 C0018784 \| sensorineural hearing loss \| 1 C0042109 \| urticaria \| 1 C0042900 \| vitiligo \| 1 C0042373 \| vascular disorders \| 1 C0022408 \| arthropathy \| 1 C0004610 \| bacteremia \| 1 C0151205 \| periorbital edema \| 1 C0026848 \| myopathy \| 1 C0043037 \| warts \| 1 C0340643 \| aortic dissection \| 1 C0029166 \| oral manifestations \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:21)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10516487	21900951	55024	BANK1	umls:C0409974	BeFree	The dual effect of the lupus-associated polymorphism rs10516487 on BANK1 gene expression and protein localization.	0.000542884	2012	BANK1	4	101829919	G	T,A
rs1143679	22586164	3684	ITGAM	umls:C0409974	BeFree	The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes.	0.002171535	2012	ITGAM	16	31265490	G	A
rs1143679	24608226	3684	ITGAM	umls:C0409974	BeFree	Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM.	0.002171535	2015	ITGAM	16	31265490	G	A
rs1270942	21952918	3663	IRF5	umls:C0409974	BeFree	Importantly, our data suggest that in patients with lupus, the presence of the HLA lupus risk alleles in rs1270942 and rs3131379 increases the odds of also carrying the lupus risk allele in IRF5 (rs2070197) by 17% and 16%, respectively (P = 0.0028 and P = 0.0047, respectively).	0.01827382	2012	CFB	6	31951083	A	G
rs13023380	23441136	2547	XRCC6	umls:C0409974	BeFree	DNA carrying the intronic risk allele rs13023380 showed reduced binding efficiency to a cellular protein complex including nucleolin and lupus autoantigen Ku70/80, and showed reduced transcriptional activity in vivo.	0.000542884	2013	IFIH1	2	162297853	G	A
rs13023380	23441136	4691	NCL	umls:C0409974	BeFree	DNA carrying the intronic risk allele rs13023380 showed reduced binding efficiency to a cellular protein complex including nucleolin and lupus autoantigen Ku70/80, and showed reduced transcriptional activity in vivo.	0.000271442	2013	IFIH1	2	162297853	G	A
rs2070197	21952918	3663	IRF5	umls:C0409974	BeFree	Importantly, our data suggest that in patients with lupus, the presence of the HLA lupus risk alleles in rs1270942 and rs3131379 increases the odds of also carrying the lupus risk allele in IRF5 (rs2070197) by 17% and 16%, respectively (P = 0.0028 and P = 0.0047, respectively).	0.01827382	2012	IRF5	7	128948946	T	C
rs2476601	23359562	26191	PTPN22	umls:C0409974	BeFree	The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide polymorphism, C1858T, associated with several autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus.	0.026851677	2013	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	18759295	26191	PTPN22	umls:C0409974	BeFree	The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus.	0.026851677	2008	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	16052563	26191	PTPN22	umls:C0409974	GAD	[ The R620W polymorphism of the PTPN22 gene is not a major risk allele for SLE susceptibility in our sample of Caucasian individuals from northern America, the UK, or Finland, but it appears to be a risk factor for the concurrent autoimmune diseases of aut]	0.026851677	2005	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	15273934	26191	PTPN22	umls:C0409974	GAD	[Together with recent evidence showing association of this SNP with type 1 diabetes and rheumatoid arthritis, these data provide compelling evidence that PTPN22 plays a fundamental role in regulating the immune system and the development of autoimmunity.]	0.026851677	2004	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	18759295	7124	TNF	umls:C0409974	BeFree	The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus.	0.02036941	2008	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	23359562	52	ACP1	umls:C0409974	BeFree	The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide polymorphism, C1858T, associated with several autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus.	0.000271442	2013	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	15759012	26191	PTPN22	umls:C0409974	GAD	[Altogether, we have provided further evidence of an association between autoimmune diseases and the 1858C>T polymorphism in PTPN22.]	0.026851677	2005	PTPN22;AP4B1-AS1	1	113834946	A	G
rs3131379	21952918	3663	IRF5	umls:C0409974	BeFree	Importantly, our data suggest that in patients with lupus, the presence of the HLA lupus risk alleles in rs1270942 and rs3131379 increases the odds of also carrying the lupus risk allele in IRF5 (rs2070197) by 17% and 16%, respectively (P = 0.0028 and P = 0.0047, respectively).	0.01827382	2012	MSH5;MSH5-SAPCD1	6	31753256	G	A
rs3813946	17360460	1380	CR2	umls:C0409974	BeFree	Single-nucleotide polymorphism 1 (rs3813946), located in the 5' untranslated region of the CR2 gene, altered transcriptional activity, suggesting a potential mechanism by which CR2 could contribute to the development of lupus.	0.003181358	2007	CR2	1	207454348	T	C
rs4649203	24070858	4792	NFKBIA	umls:C0409974	BeFree	We found that these two SNPs (rs8016947 and rs4649203) in two loci (NFKBIA and IL28RA) were associated with psoriasis and SLE with genome-wide significance (Pcombined<5×10(-8) in psoriasis and Pcombined<5×10(-8) in SLE): rs8016947 at NFKBIA (Pcombined-psoriasis=3.90×10(-10), Pcombined-SLE=1.08×10(-13)) and rs4649203 at IL28RA (Pcombined-psoriasis=3.91×10(-12), Pcombined-SLE=9.90×10(-9)).	0.000271442	2014	NA	1	24193430	G	A
rs4649203	24070858	163702	IFNLR1	umls:C0409974	BeFree	We found that these two SNPs (rs8016947 and rs4649203) in two loci (NFKBIA and IL28RA) were associated with psoriasis and SLE with genome-wide significance (Pcombined<5×10(-8) in psoriasis and Pcombined<5×10(-8) in SLE): rs8016947 at NFKBIA (Pcombined-psoriasis=3.90×10(-10), Pcombined-SLE=1.08×10(-13)) and rs4649203 at IL28RA (Pcombined-psoriasis=3.91×10(-12), Pcombined-SLE=9.90×10(-9)).	0.000271442	2014	NA	1	24193430	G	A
rs72556554	21937424	11277	TREX1	umls:C0409974	BeFree	The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.	0.001900093	2011	TREX1	3	48466996	G	A,C
rs8016947	24070858	4792	NFKBIA	umls:C0409974	BeFree	We found that these two SNPs (rs8016947 and rs4649203) in two loci (NFKBIA and IL28RA) were associated with psoriasis and SLE with genome-wide significance (Pcombined<5×10(-8) in psoriasis and Pcombined<5×10(-8) in SLE): rs8016947 at NFKBIA (Pcombined-psoriasis=3.90×10(-10), Pcombined-SLE=1.08×10(-13)) and rs4649203 at IL28RA (Pcombined-psoriasis=3.91×10(-12), Pcombined-SLE=9.90×10(-9)).	0.000271442	2014	NA	14	35363460	T	G
rs8016947	24070858	163702	IFNLR1	umls:C0409974	BeFree	We found that these two SNPs (rs8016947 and rs4649203) in two loci (NFKBIA and IL28RA) were associated with psoriasis and SLE with genome-wide significance (Pcombined<5×10(-8) in psoriasis and Pcombined<5×10(-8) in SLE): rs8016947 at NFKBIA (Pcombined-psoriasis=3.90×10(-10), Pcombined-SLE=1.08×10(-13)) and rs4649203 at IL28RA (Pcombined-psoriasis=3.91×10(-12), Pcombined-SLE=9.90×10(-9)).	0.000271442	2014	NA	14	35363460	T	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:5)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	195531423	rs1890645	T	C	rs1890645	20662065	4.00E-06	NA	2.98	[1.88-4.73]	116 European American ancestry cases; 3,351 European American ancestry controls	European American(3467)	ALL(3467)	EUR(3467)	ALL(3467)	Neonatal lupus	HPOID:0002960	Autoimmunity	DOID:8857	lupus erythematosus	D008180	Lupus Erythematosus, Systemic	EFOID:0004537	neonatal systemic lupus erthematosus	Lupus erythematosus	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
6	31448976	rs3099844	C	A	rs3099844	20662065	5.00E-10	NA	3.34	[2.29-4.89]	116 European American ancestry cases; 3,351 European American ancestry controls	European American(3467)	ALL(3467)	EUR(3467)	ALL(3467)	Neonatal lupus	HPOID:0002960	Autoimmunity	DOID:8857	lupus erythematosus	D008180	Lupus Erythematosus, Systemic	EFOID:0004537	neonatal systemic lupus erthematosus	Lupus erythematosus	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
10	4719796	rs1391511	A	G	rs1391511	20662065	7.00E-06	NA	1.84	[1.41-2.40]	116 European American ancestry cases; 3,351 European American ancestry controls	European American(3467)	ALL(3467)	EUR(3467)	ALL(3467)	Neonatal lupus	HPOID:0002960	Autoimmunity	DOID:8857	lupus erythematosus	D008180	Lupus Erythematosus, Systemic	EFOID:0004537	neonatal systemic lupus erthematosus	Lupus erythematosus	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
12	84008275	rs2403106	A	G	rs2403106	20662065	3.00E-06	NA	2.48	[1.70-3.61]	116 European American ancestry cases; 3,351 European American ancestry controls	European American(3467)	ALL(3467)	EUR(3467)	ALL(3467)	Neonatal lupus	HPOID:0002960	Autoimmunity	DOID:8857	lupus erythematosus	D008180	Lupus Erythematosus, Systemic	EFOID:0004537	neonatal systemic lupus erthematosus	Lupus erythematosus	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
21	40056423	rs743446	A	C	rs743446	20662065	5.00E-06	NA	2.4	[1.64-3.49]	116 European American ancestry cases; 3,351 European American ancestry controls	European American(3467)	ALL(3467)	EUR(3467)	ALL(3467)	Neonatal lupus	HPOID:0002960	Autoimmunity	DOID:8857	lupus erythematosus	D008180	Lupus Erythematosus, Systemic	EFOID:0004537	neonatal systemic lupus erthematosus	Lupus erythematosus	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	804
Disease	lupus erythematosus
Case	(Waiting for update.)

eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine

What is lupus?

Who gets lupus?

What causes lupus?

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